Title: Briar Station
Setting: Space Station, near the Briar Patch
Era: Post Dominion War
When what was going on on the Ba'ku world was discovered by the Enterprise-E, Starfleet realized that the Briar Patch, and the planet within, were destined to become something of a point of contention, regardless of it being within Federation Space.
As a result, a space station was begun at that point, and it has come online. The Federation, knowing that diplomacy at this point would be better served than keeping the Patch to themselves, opened a number of diplomatic seats for the station, a Romulan and a Klingon seat most importantly.
The series would feature the aftershocks of the "Fountain of Youth"'s discovery, as well as the creation of such things as research into metaphasics, a hospital facility on the Ba'ku planet, the reintegration of the So'Na and the Ba'ku, the fitting of ships with engine modifications so they could function in the Patch, Exploration of the Patch, various subterfuge and intelligence agencies wanting the place for themselves, not to mention Section 31.
The players would be the crew of said station, or ambassadors, or other important figures. There would be the "Talon scout ship" attached to this station as well. Many positions would be available:
Federation: Station Commander, Executive Officer, Ops, Engineer (for the ship refittings and the like), Security/Tactical, Chief Medical Officer, Science Officer, Pilot for the Talon-class ship, and so forth.
Diplomatic: Romulan, Klingon, So'Na, Ba'Ku.
Civillian/Other: Merchant Marine, Civillian famlies, "The Mall" shopowners/clerks/bartenders/etc.
The Doc