I have been pondering the concept of bio engined space ships . The one we used in a super hero game was free thinking being . The bio ship was created to be a scout craft . It was well armed for self defense but disliked combat . I will not bored everyone will recounting each adventure .
Here are a few thoughts about bio ship
Advances
Self repairing , cheaper and faster to build , telepathy with crew with in the ship or close by
Downside
The ship can get sick like you and me . will need special diet needs , repair time is longer then mechancail ship and ship has dislike of planet , other ships or races
Other factors
the ship has it own mind , so it may not want to go somewhere or refused to follows orders
The ship need to take a vacation every couple of years