Well, I'm using the "latest" rules set, but I've been doing some retro-Trek gaming, and while I might have flexed continuity a bit I've kept it pretty well on track.
I ran a Starfleet mini-campaign set in the years 2241-2245; since theres no holodecks just yet, I used the solar system as the training grounds. The PCs used a Daedalus-class ship, the
USS Drake for their extraplanetary excursions. I borrowed the plot of the novel
Collision Course for the "senior year" action. I also noted the invention of the duotronic circuit and the "advanced" Class I starships scheduled to go into service in 2245 (from the Starfleet Technical Manual).
Upon graduation, the PCs shipped out aboard the
USS Enterprise under Capt Robert April in an adventure loosely based on the novel
Final Frontier.
A year later, the players (still crewing under April) are the first to arrive at Tarsus IV after Kodos' madcap notions of preserving the best and brightest. Some elements borrowed from
Collision Course, and they meet the only onscreen survivors of the massacre: Tom Leighton, Kevin Riley and James T. Kirk.
Fast forward another year, and the players are delivering a small survey ship to the planet Faramond when they are jumped by those cold blooded killers the Sharks from the flashback portions of
Best Destiny.
We've hit a major time warp, and the next time we play it will be 2251. I've told the players to come up with a couple of years worth of offscreen character development before they are reunited aboard another ship. After three more adventures they'll be getting their own ship to command...just in time for the Four Years War!
So, I guess you could say I've been delving into some old school Trek. Its been going great so far.