Slight correction to the above: The Runabout got wasted too - the Defiant beamed Odo and Garak off it just prior to its destruction.
Although Sisko said no ships survived, the Defiant was hot-tailing it out of Dodge at the time and might not have noticed if, say, a Romulan Warbird managed to cloak and get away. That'd be my best bet if I wanted to run a campaign based around "the one that got away".
"That might have been the biggest mistake of my life..."
"It is unlikely. I predict there is scope for even greater mistakes in the future given your obvious talent for them."
Vila and Orac, Blake's Seven