If you need enemies then I suggest the Ferengi. Firstly, whatever importance the system has it must have a "market value". Secondly, the Ferengi could aid both sides (whichever that may be) by providing "access" to advisors, mercs and the like. Hiring out muscle in a way so each side can levy wars by proxy upon each other.
The Ferengi's goal could be to destabilize the region and make a grab for the planet/starbase/resource. All for profits sake of course. Since it could become a burgeoning center for space travel, maybe a few shops setup near or in the starbase. Your friendly local Ferengis setup shop (and smuggle weapons to each side).
Just my thoughts...
"The misery of being exploited by capitalists is nothing compared to the misery of not being exploited at all."
-Joan Robinson, economist