Do the merchant thing, but on the border with the Cardies post-DS9. A plot line: salvaging war surplus; they'd have tons of competition -- Ferengi, Orion, and otherwise.
The big issues would matter to them, so the interest in the politics. With peace talks ongoing, both sides are scrambling to snatch up systems and space before a solid deal on the borders, etc. comes into play. There will be forces trying to protect military secrets by trying to get to the surplus first. The worlds they are operating out of will possibly be changing hands as negotiations for the border deal are crystalizing. Legality of some of the stuff their collecting might change, or access to areas might become restricted.
All sorts of stuff where the big issues could interfere with their day-to-day operations.
"War is an ugly thing but not the ugliest of things; the decayed and degraded state of moral and patriotic feelings which thinks that nothing is worth war is much worse. A man who has nothing for which he is willing to fight, nothing which is more important than his own personal safety, is a miserable creature and has no chance of being free unless made and kept so by the exertions of better men than himself."
John Stuart Mill