Ran a couple of campaigns with all rogue (but good-hearted) rogue groups:
1) A flipside of the "Think Tank" from Voyager. Scientist and engineer PCs who roamed the AQ in their own ship helping people solve problems (and who Starfleet couldn't help due to the Prime Directive).
2) "Noble renegades" campaign with a bunch of people of dubious employment (smuggler, bounty hunter, former netgirl, ex-assassin) on the run from the authorities and former associates who wanted them dead, occasionally helping those in need. The group "leader" was the ex-assassin, who was half-Romulan and had worked for the Tal Shiar before he finally woke up to the fact that his victims weren't always "enemies of the state".
3) Traders (and part-time smugglers) in a jazzed-up freighter who got whisked Voyager-style far from the Federation (around 30,000 light-years) by a subspace anomaly and now have to get home. But without Starfleet regs and the Prime Directive the moral issues won't be quite so clear-cut...
"That might have been the biggest mistake of my life..."
"It is unlikely. I predict there is scope for even greater mistakes in the future given your obvious talent for them."
Vila and Orac, Blake's Seven