I only really have 2 players; and only one of them (my wife) is a regular. My friend Paul comes down from Sydney a few times a year for a week or two of solid role-playing, but we usually end up with him refereeing D&D and me playing (since it's the only chance I get to play).
Janetta (my wife) is as avid a Trekkie as me, though she doesn't have as good a memory for (read: "Not as obsessive-compulsive about") the technobabble and little "ins and outs" of the show.
Paul is a regular fan, but hasn't watched a lot of VOYAGER, which is kind of unfortunate since we're playing on an Intrpid class ship.
The most ironic thing about the game so far is that Janetta is playing Dr Sito Rana, Ens. Sito Jaxa's older sister and Chief Medical Officer aboard the Intrepid, and Paul is playing Ensign Nevek, a newly-graduated officer already with something of a string of heroics behind him (including exposing a Founder that had killed and replaced one of the Academy instructors).
The irony, of course, is that Sito is a Bajoran, and Nevek is the first Cardassian in Starfleet (similar setup to Worf: parents killed in Fed/Cardie war, was adopted and raised in Juneaux, Alaska by his human adoptive parents).
And they're the best of friends and have saved each others' lives on several occasions.
When you are dead, you don't know that you are dead. It is difficult only for others.
It's the same when you are stupid...