...in your games?
In our campaign:
Picard: promoted to RADM in 2376, made head of Fleet Operations (hell, he secretly ran the Federation from his ready room, it seemed...)
Riker: married Troi, military attache to Betazed. Never got a ship, but did get his captaincy thanks to his space daddy, Picard. You don't turn down 4 promotions in a row and get your own ship.
Troi: now Federation ambassador to Betazed; she's replacing her aging mum. Retired from Starfleet.
Data: promoted (finally) to CDR in 2376 & given a Steamrunner. In 2378, promoted CPT and given USS James Kirk, an aging Ambassador.
LaForge: chief development engineer, Galaxy upgrade project at SESS (Galor IV). Captain rank.
Crusher: Starfleet Medical comandant. Captain rank
Wesley: who cares...?
Sisko: lost in the wormhole.
Jake Sisko: annoying Arnett-like reporter on GNN.
Odo: didn't watch the show, so don't know what they did with him. Still security chief on DS9 in our campaign.
Bashir: teaching at Starfleet Academy, medical.
Kira: General and head of Bajoran military integration into Starfleet.
Dax: hadn't even thought about it...
Worf: still ambassador to Qo'nos. Full CDR.
The entire crew of Voyager: dead in the first season.
MInor characters that have become important:
CPT Elizabeth Shelby: after the Borg thing was a big shot at the Joint Chiefs and PLanning. Had her own command in the war, and now commands Enterprise.
VADM Ed Jellico: CinC, 16th Fleet, Mobile. Flagship is Enterprise, most of the time.
CPT Bruce Maddox: finally cracked the android problem in 2374. First Daystrom android prototype Isis finished in 2376. 2378 saw new rights trials for androids in Federation Council subcommittee; revealed Maddox had 'inappropriate relations' with Isis while in socialization phase. Quietly retired.