Interesting idea; I've always wondered how the FED would handle an anti or Bizzaro FED. A group of united systems that came together in peace and exploration. As they discover less advanced species, their Prime Directive calls for them to help bring them up closer to their standard of living/tech/culture. For instance, if this group pulled into orbit around 21st century Earth, they would begin a campaign to help us reduce environmental damage, end worldwide violence and poverty, and attempt to prepare Earth to become part of their organization.
I can see that process being like any number of sci-fi movies, but what always makes me smile is when I imagine one of their captains talking to SF captain: "What do you mean you can't interfere? Those people are dying because they don't have the medical knowledge to stop the plague. Ask your Chief Medical and Science officers, Captain. They could cure this disease in a WEEK if you let them. Lucky for these poor people WE WILL CURE THEM!"
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"Yes, it's the Apocalypse alright. I always thought I'd have a hand in it"
Professor Farnsworth