I picked up Module Prime Alpha at the weekend. From a general Trek RPG point of view the material that translates the most easily are the deck plans of the Burke class frigate (a small TOS Starfleet vessel).
The rest of the book is split between rules material (though the piece on inter-species medicine can provide some ideas for other systems) and background on the Hydrans. The Hydrans are a very alien race (three 'arms' - tentacles actually, three legs, live on smaller gas giants) and as they don't have a border with the Federation (the Klingons are in between) it wouldn't be too hard to place them in a conventional Trek campaign without screwing up continuity.
"And all I ask is a tall ship, and a star to steer her by."
"Though a cloaking device, pulsed phaser cannons
and a full load of quantum torpedoes would be quite nice too."