Well, Styro suggested I post this...
STAR TREK: ATHENA
This is the current campaign for our game. Set in 2382 on the Akira -class ship, Athena. The ship is sentient, with the latest computers Starfleet has to offer. The ship is tied to an avatar that is made from meidcal cybernetics, making her seem just as 'real' as normal humans (we're using Julie Strain for the body/face -- she has that kick-ass goddess feel to her, or so the computer thought when she chose the body form for her avatar.) He brain is a more advanced positronic with biogel pack memory. She packs 8x the computational ability of Data.
Athena is the latest design out of Daystrom, which cracked the positronics problem in 2376 with the first android, Isis. There are more androids on the way, and Starfleet is still trying to decide about the praticality or safety of sentient starships. They can't legally stop the manufacture of new androids -- it is the equivalent of reproduction for Isis...they can't deny her right to 'have children'.
There's a building problem between organics, who fear that this new 'species' -- much more intelligent, adaptive, and resilient than any other species in the Federation might rise to the top of the sociopolitical food chain. Some see the 'human-like' creatures as a diminution of the worth of humans. Why is being human important when machines are as smart, have feelings....perhaps even souls? Religion is starting to rear it's head in response to these social disturbances...
Meanwhile, in the Kelinan Reach, Athena & her crew are exploring. They will come into contact with the series bad guy: a machine race that views the biologics as not lesser, but obsolete, life forms. These critters are composed of nanotubule-type machines that make these creatures a 'unified organism'. The anotubules can be used for processing, motor function, 'skin', etc. They can change their appearance to fit anything. They can communicate almost instantaneously with each other. They are individuals, but can operate in hive style. They reproduce by combining programming. They can be gaseous, solid, or fluid in form, can combine to form a larger entity -- up to starship size. They can infect biologics and break down the organic material for nanotubules -- turning them into machines versions of the biologic (they can map and replicate the memories and personality of the people.)
These guys will wind up working to liberate their machine counterparts in the UFP, as well as bring the weak, slow organics into their machine fold.